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10.1371/journal.pone.0187307 PLoS One 127 MinterM

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Including everyone who started the trial, not just completers, the average was 11.1%

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Thus, the prevalence of obesity in patients with PWS varies according to age, from 40% in pediatric subjects and up to 8298% in adults [24, 28]

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Mitochondrial ROS activate pro-hypertrophic pathways like calcineurin/NFAT, and impaired mitophagy causes the accumulation of damaged mitochondria in hypertrophied hearts, reducing contractile efficiency

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